lupus is a complex, chronic autoimmune disease that causes the immune system to attack healthy tissue. “astrazeneca is a great place to work if you want to be challenged and if you want to have the ability to see the impact of your work towards developing medicines for patients with respiratory diseases like copd.” refers to assets that are in phase iii or that have been submitted for regulatory approval and may include assets that are now launched in one or more major markets.
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you may notice problems with the display of certain parts of an article in other ereaders. the patient presented with pruritis and jaundice 13 days after receiving a bnt162b2 mrna (pfizer-biontech) covid-19 vaccine, which may be the first report of covid-19 vaccine-associated liver injury. he was referred to our emergency department after a finding of markedly abnormal liver function tests on routine blood tests and was asymptomatic at the time. antinuclear antibody was positive at a titre of 1:160 in a speckled pattern.
no thrombus was identified in the portal, splenic, hepatic, or superior mesenteric veins. he was commenced on 60 mg of prednisolone daily, admitted to hospital, and had a liver biopsy 3 days after commencing the corticosteroids. his prednisolone has been weaned over the following month and is now down to 20 mg/day, with an alt of 163 u/l and bilirubin of 7 μmol/l (fig. in contrast to the communique published by bril et al.,1 our patient received the oxford-astrazeneca vaccine and did not have any apparent confounding factors such as pregnancy. in this case, however, the patient is a practicing physician with excellent health literacy and we feel it is unlikely that other potential aetiologies were missed on history.
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