the results indicated that statins have no significant adverse effect on sleep duration and efficiency, entry to stage i, or latency to stage i sleep, but significantly reduce wake time and number of awakenings. [9] noted that lovastatin therapy in comparison to pravastatin was associated with increased time in stage 1, wake time and number of weakness. taking into account the divergent data, we performed a meta-analysis to investigate the effect of statin therapy on sleep parameters using the polysomnography method. random-effects meta-regression was performed to evaluate the association between calculated wmd and potential confounders including duration of treatment with statins and changes in plasma ldl-c concentrations following treatment. the impact of statin therapy on psg indices of sleep was reported in 9 treatment arms.
these effect sizes were not sensitive to any single trial, apart from the sensitivity of pooled effect size for the wake time to the study by kamei et al. the results are mixed, and no conclusive evidence exists that statin therapy is associated with sleep disturbances, and there is not enough data to confirm the causality of statin therapy on sleep disturbances [2, 3]. [21] aimed to evaluate the effect of pravastatin on sleep in 5 healthy adults treated for 16 days. [20], found that subjective ratings of sleep initiation and maintenance during and after therapy were not significantly different between the groups. in conclusion, the meta-analysis of available rcts does not suggest any significant adverse effects of statin therapy on sleep duration and its efficiency. lower plot shows leave-one-out sensitivity analysis forest plot detailing weighted mean difference and 95% confidence intervals for the impact of statin therapy on latency to stage i sleep.
a popular cholesterol-lowering drug may be to blame. in a new study, those who took the statin drug zocor reported they had a significantly worse quality of sleep than those who took a placebo or pravachol, another statin drug, says researcher beatrice golomb, md, an associate professor of medicine at the university of california, san diego. the study involved 1,016 people with no signs of heart disease and ldl “bad” cholesterol levels between 115 and 190. ldl levels below 100 are optimal, according to the american heart association. they were randomly assigned to zocor, pravachol, or a placebo for six months. zocor and pravachol dissolve in the body differently, says gordon tomaselli, md, chairman of the committee that picked the studies to highlight at the meeting.
zocor dissolves in fat, so it can more easily penetrate cell membranes and cross the blood-brain barrier into the brain. “it’s easy to theorize that if you get a foreign substance in the brain, it might affect sleep, cognition and other processes controlled by the brain,” tomaselli tells webmd. merck, the maker of zocor, says in a statement that it conducted sleep studies with zocor, pravachol, and a placebo and found no difference with regard to sleep disturbances between zocor and the placebo. additionally, in a study of more than 20,000 patients, people taking zocor were no more likely to stop taking it because of sleep disorders than those on placebo, merck says. gordon tomaselli, md, chairman, aha committee on scientific session program; chief of cardiology, johns hopkins university school of medicine, baltimore. medicine for people in need web site.
statin use might be associated with an increased risk of sleep disturbances including insomnia, but the evidence regarding sleep changes following statin medications that commonly cause insomnia include antidepressants, decongestants, beta blockers, and statins. talk to your provider if you insomnia is listed as a possible side effect on the labeling of all statin drugs. the findings were reported at the american heart, when to take atorvastatin morning or night, atorvastatin nightmares, atorvastatin nightmares, atorvastatin side effects, do all statins cause insomnia.
the current evidence, from well-run research trials of more than 100,000 patients, is that statins do not cause insomnia or any other sleep disturbance, compared with a dummy pill (placebo). researchers have found that fat-soluble statins u2014 which include lipitor, mevacor, vytorin and zocor u2014 are more likely to cause insomnia or nightmares because they can more easily penetrate cell membranes and make their way across the blood-brain barrier, which protects the brain from chemicals in the blood. researchers have found that fat-soluble statins including lipitor, mevacor, vytorin and zocor are more likely to cause insomnia or read about the side effects of statins. there are many different side effects, which vary depending on the specific type of statin. “that being said, however, insomnia is an adverse event associated with statins and is included in the product label for this class of, which drugs cause sleeplessness, drugs that keep you awake all night.
When you try to get related information on atorvastatin insomnia, you may look for related areas. when to take atorvastatin morning or night, atorvastatin nightmares, atorvastatin side effects, do all statins cause insomnia, which drugs cause sleeplessness, drugs that keep you awake all night.