it has now been concluded by medsafe, other national regulators (such as the fda) and the company, pfizer, that myocarditis (inflammation of the heart muscle) is a rare side effect of vaccination with comirnaty. as it is sometimes difficult to distinguish between myocarditis and pericarditis (inflammation of the sac surrounding the heart), the warning will relate to both conditions. the benefits of vaccination with comirnaty continue to outweigh the risk of experiencing a side effect for people of all ages in the approved indication. there are many possible causes of myocarditis, the most common being viral infection. over 100 people are discharged from hospital with a principle diagnosis of myocarditis in new zealand every year. young men (aged 16–20 years) are especially at risk of experiencing myocarditis, while women are affected most after menopause.5 the estimated rate of hospitalisation due to myocarditis in new zealand is around 2 per 100,000 person years (interim data safe study led by associate professor helen petousis-harris, university of auckland).
the short- and long-term implications of sars cov-2 infection-induced myocarditis are being monitored.6 the united states was among the first countries starting to vaccinate people from 12 years of age with comirnaty. up to 19 july 2021, the centre for adverse reactions monitoring (carm) has received 9 cases of myocarditis, 5 cases of pericarditis and 4 cases of myopericarditis. not all the cases reported to date were admitted to hospital. to date there has been no clear increase in cases of myocarditis in new zealand. the age ranges are shown in figure 1. the new zealand data sheet for comirnaty will be updated shortly with a myocarditis and pericarditis warning and precaution.
“overwhelmingly, data continue to indicate that the benefits of covid-19 vaccination — 91% effective at preventing complications of severe covid-19 infection including hospitalization and death — far exceed the very rare risks of adverse events, including myocarditis,” said dr. donald lloyd-jones, president of the american heart association, who was not involved in the study. the u.s. centers for disease control and prevention has said there appears to be a link between mrna covid-19 vaccines and myocarditis, particularly in people under 39 years of age. to learn more, researchers analyzed data from 139 12- to 20-year-olds in the united states and canada who had probable or confirmed myocarditis within a month of receiving a covid-19 vaccine. in all, 97.8% of the cases followed an mrna vaccine, with 91.4% occurring after the second dose.
chest pain was the most common symptom (99.3%), and fever and shortness of breath occurred in 30.9% and 27.3% of patients, respectively. “these data suggest that most cases of suspected covid-19 vaccine-related myocarditis in people younger than 21 are mild and resolve quickly,” said study first author dr. dongngan truong, associate professor of pediatrics at the university of utah. she said researchers await further studies to better understand long-term outcomes for patients who have had covid vaccination-related myocarditis. “we also need to study the risk factors and mechanisms for this rare complication,” truong said in a journal news release.
both myocarditis and pericarditis have the following symptoms: chest pain; shortness of breath; feelings of having a fast-beating, fluttering, or pounding heart. in the first few days after your vaccination seek medical attention if you experience new onset chest pain, shortness of breath or an abnormal chest pain was the most common reported symptom, along with fever and shortness of breath. the median hospital stay was three days, with 65, .
symptoms of myocarditis or pericarditis typically appear within 1 to 5 days of vaccination. people who experience any of these symptoms after having an mrna covid-19 vaccine should seek prompt medical attention: chest pain. pressure or discomfort in the chest. symptoms began a median of two days after vaccination — meaning half started sooner, half later. chest pain was the most common symptom if you notice myocarditis symptoms or signs of an allergic reaction like hives, swelling, or wheezing after getting the vaccine, let your doctor know about it watch out for these symptoms after a pfizer or moderna vaccine pain, pressure or discomfort in your chest an irregular heartbeat, skipped, .
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