the .gov means it’s official. the site is secure. the objective of this study was to conduct a meta-analysis of the clinical impact of duloxetine treatment on sleep in adults with major depressive disorder.
sleep outcome was assessed by the hamilton depression rating scale-17 (hamd(17)) sleep items (onset latency, middle awakening, and early awakening) and their sum (insomnia subscale) and by occurrence of sleep-related treatment-emergent adverse events (teaes). efficacy was measured by hamd(17) maier subscale scores. duloxetine-treated patients improved more on the hamd(17) sleep subscale compared with placebo-treated patients (mean=-1.2 vs. -1.1, p< or =0.05). compared with placebo, duloxetine treatment was associated with a positive, but negligible, benefit on clinical ratings of insomnia and with more frequent sleep-related teaes that did not negatively impact overall efficacy for major depressive disorder.
with input from you, your health care provider will assess how long you will need to take the medicine. it is important to discuss the risks and benefits of treatment with your doctor and caregivers. if you miss a dose of duloxetine take it as soon as you remember, unless it is closer to the time of your next dose.
the risk may be greater in patients also taking medications for high blood pressure. depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. last updated: january 2016. this information is being provided as a community outreach effort of the college of psychiatric and neurologic pharmacists. this information contains a summary of important points and is not an exhaustive review of information about the medication.
not being able to sleep (also called insomnia) is one of the most common side effects reported by people taking cymbalta. compared with placebo, duloxetine treatment was associated with a positive, but negligible, benefit on clinical ratings of insomnia and with more frequent sleep headache, nausea, diarrhea, dry mouth, decreased appetite, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia), .
unfortunately, insomnia is a common side effect experienced by some people who take cymbalta. roughly 10% or more of patients taking cymbalta report insomnia. insomnia can mean difficulty falling asleep, difficulty staying asleep, waking up earlier than desired, or waking up and still feeling tired. insomnia (trouble falling asleep or staying asleep) can occur with cymbalta. in studies, this side effect was more commonly reported in people taking the drug for long-term musculoskeletal pain. with insomnia, you can have trouble falling asleep or staying asleep. it can cause you to wake up too early. if you experience sleep issues while cymbalta is an effective drug in many neuropsychiatric conditions, it is known to have sleep-related side effects such as insomnia, daytime sleepiness duloxetine. brand names: cymbalta, yentreve. find out how duloxetine treats depression, anxiety, nerve pain and urinary incontinence, and how to take it., .
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