disease related to sleeplessness

the public health consequences of sleep loss and sleep-related disorders are far from benign. the main symptom of sleep loss is excessive daytime sleepiness, but other symptoms include depressed mood and poor memory or concentration (dinges et al., 2005). another common finding is the relationship that adverse effects occur with either short or long sleep duration, as compared to a sleep time of 7 to 8 hours. in the sleep heart health study, which is a community-based cohort, adults (middle-aged and older) who reported 5 hours of sleep or less were 2.5 times more likely to have diabetes, compared with those who slept 7 to 8 hours per night (figure 3-3, [gottlieb et al., 2005]). the relationship between shorter sleep times and impaired glucose tolerance is also supported by an experimental study in which 11 healthy male volunteers were restricted to 4 hours of sleep for a total of six nights (spiegel et al., 1999). on the other hand, a large, 3-year longitudinal study of more than 2,200 middle school students (ages 11 to 14) found that self-reported sleep loss was associated with more depressive symptoms and lower self-esteem over time (fredriksen et al., 2004). the most effective treatment for sleep loss is to sleep longer or take a short nap lasting no more than 2 hours (veasey et al., 2002), and to have a better understanding of proper sleep habits. although osa can occur in children of any age, it is most common at preschool ages, a time coincident with tonsils and adenoids being largest relative to the underlying airway (jeans et al., 1981). case-control studies reveal that approximately 30 percent of patients diagnosed with essential hypertension (hypertension in which the underlying cause cannot be determined) turn out to have sleep apnea (partinen and hublin, 2005). as will be discussed in the next section, osa is associated with glucose intolerance and diabetes, both of which are independent risk factors for cardiovascular disease. the findings suggest that osa contributes to the onset of diabetes through the development of glucose intolerance and insulin resistance, which are established pathophysiological processes in diabetes (martin et al., 1992). the relationship between osa and metabolic changes that may lead to diabetes is reinforced by studies of the benefits of cpap. in simplest terms, osa is caused by narrowing or collapse of the airway as a result of anatomical and physiological abnormalities in pharyngeal structures. the comorbidity of sleep disorders with psychiatric disorders is covered later in this chapter. the 24-hour pattern of cortisol and acth secretion is different, however, from that in individuals who are chronically stressed. the comorbidity, or coexistence, of a full-blown sleep disorder (particularly insomnia and hypersomnia) with a psychiatric disorder is also common. in generalized anxiety disorder, for example, the symptoms of fatigue and irritability used to diagnose it are often the result of a sleep disturbance, which itself is also a diagnostic symptom. the authors hypothesize that increased metabolism in emotional pathways with depression may increase emotional arousal and thereby adversely affect sleep (nofzinger et al., 2005). one hypothesis is that common pathways are the amygdala and other limbic structures of the brain (nofzinger et al., 2005). narcolepsy is associated with a number of symptoms (anic-labat et al., 1999; overeem et al., 2002), including the following: clinical laboratory findings in narcolepsy and hypersomnia. most of the knowledge in this area pertains to narcolepsy with cataplexy, which affects males and females equally.




however, as with other pharmaceuticals designed to treat sleep problems, large-scale clinical trails have not examined the efficacy and safety of drugs to treat narcolepsy in children and adolescents. they are categorized as primary parasomnias, which predominantly occur during the sleep state, and secondary parasomnias, which are complications associated with disorders of organ systems that occur during sleep. rem sleep behavior disorder is frequently associated with neurological disorders and it has been suggested that it could be an early sign of neurodegeneration (olson et al., 2000). there is limited information regarding the etiology of sleep disorders associated with alzheimer’s disease and other conditions that cause dementia. individuals suffer from increased sleep latency and frequent awakenings, spending as much as 30 to 40 percent of the night awake (kales et al., 1971; bergonzi et al., 1975). epilepsy refers to a group of various disorders characterized by abnormal electrical activity in the brain that manifests itself in individuals as a loss of or impaired consciousness and abnormal movements and behaviors. studies investigating the association between sleep-disordered breathing and stroke found that 60 to 70 percent of individuals who have suffered a stroke exhibit sleep-disordered breathing with an apnea-hypopnea index of 10 or greater (dyken et al., 1996; bassetti et al., 1996). rather, treatments depend on the specific symptoms and are similar to the treatments of sleep disorders that arise indepen dent of a stroke. smoking, drinking, or drug use by the mother during gestation are linked to an increased chance of sids-related deaths in infants, as is infant exposure to smoke (schoendorf and kiely, 1992; aap, 2000; iyasu et al., 2002). iron in turn is necessary for the synthesis of dopamine and the activity of the d2 dopamine receptor (turjanski et al., 1999). they are more frequent in the beginning of the night and cluster together. children with adhd have an increased prevalence of periodic limb movements (picchietti et al., 1998), and children with periodic limb movement disorders are more likely to have adhd (picchietti et al., 1999; ozminkowski et al., 2004). this is complicated by the unique effects that specific infections have on sleep patterns and the absence of a large body of clinical research. it is characterized by episodes of nocturnal insomnia and daytime sleep, but not hypersomnia (lundkvist et al., 2004). however, objective measures of sleep in the patients and analyses of clinical correlates are very limited. theophylline, a respiratory stimulant and bronchodilator, is in the same class of medications as caffeine and can likewise disturb sleep—even in healthy subjects (kaplan et al., 1993). the exact prevalence of delayed sleep phase syndrome in the general population is unknown. in addition to a structured sleep-wake schedule and good sleep hygiene practices, potential therapies include resetting the circadian pacemaker with bright light, melatonin, or a combination of both. it is also hypothesized that administration of low levels of melatonin in the early morning may also be used (lewy et al., 1996), though there are no published reports verifying this option. the amount of time it takes to fall asleep (sleep latency) and the occurrence of rapid eye movement (rem) sleep is recorded. cerebrospinal fluid (csf) hypocretin-1, also called orexin-a, is a neuropeptide involved in the cause of narcolepsy and cataplexy.

a sleep disturbance may be a symptom of a health issue or an adverse effect of therapy to treat the problem. people with diabetes whose blood sugar levels are not well controlled may experience sleep problems due to: heart failure is a condition characterized by a gradual decline in the heart’s ability to “pump”, or circulate blood adequately. kidney disease can cause waste products to build up in the blood and can result in insomnia or symptoms of restless legs syndrome. breathing difficulties or fear of having an attack may make it more difficult to fall asleep, as can the use of steroids or other breathing medications that also have a stimulating effect, similar to that of caffeine.

waking up too early in the morning is a hallmark of depression, and some depressed people have difficulty falling asleep or get fitful sleep throughout the whole night. some people with schizophrenia sleep very little in the early, most severe stage of an episode. just getting in and out of bed can be a struggle, and the disease often disrupts sleep. however, the use of these medications at night is important to maintain the mobility needed to change positions in bed.

common sleep disorders like insomnia, restless legs syndrome, narcolepsy and sleep apnea can severely hurt your quality of life. gastrointestinal (gi) disorders like inflammatory bowel syndrome (ibs) and gastroesophageal reflex disease (gerd) are also linked to sleep fatal familial insomnia (ffi) is a rare genetic degenerative brain disorder. it is characterized by an inability to sleep (insomnia), what are the 5 types of sleep disorders, what are the most common causes of sleep problems, how to cure insomnia in 12 minutes, causes of insomnia in females, causes of insomnia in females.

examples of conditions linked with insomnia include chronic pain, cancer, diabetes, heart disease, asthma, gastroesophageal reflux disease (gerd), overactive thyroid, parkinson’s disease and alzheimer’s disease. insomnia – being unable to fall asleep and stay asleep. this is the most common sleep disorder. sleep apnea – a breathing disorder in which you what are the different types of sleep disorders? insomnia refers to the inability to fall asleep or to remain asleep. sleep apnea is characterized by pauses data from the wisconsin sleep cohort also show that individuals with osa have reduced levels of physical activity; osa-related sleepiness may, insomnia, types of sleeping disorders.

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