we are very pleased to present a two-part video series by neuroscientist amanda freeman, phd, of emory university, which describes, in layman’s terms, exactly how y-aminobutyric acid, better known as gaba, affects sleep. as dr. freeman notes, this was a paradigm shift in the thinking about sleep and gaba. the first part of this two-part video series focuses on explaining what gaba is and what role it plays in our sleep. note: if you have any questions about this gaba video series, please consult your own personal physician or *protected email*, not dr. freeman. the contents of this website, including text, graphics and other material, are for informational purposes only.
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we sought to systematically assess the effects of clarithromycin on objective vigilance and subjective sleepiness. we also sought to determine the safety and tolerability of a two week course of clarithromycin in this clinical population. eligible subjects were enrolled in a two-treatment, two-period (ab/ba) crossover trial comparing the effects of clarithromycin and matched placebo. identity of medication (clarithromycin versus placebo) was concealed by the pharmacy, using matched pills and labeled pill containers generated for each subject that were identical in appearance for placebo and clarithromycin weeks (other than sequential dates). post-hoc comparisons were performed on several subgroups of patients for each outcome that showed a significant effect of clarithromycin in the group as a whole.
for all outcomes other than scores on the stanford sleepiness scale, there was no significant difference between scores during week 1 of clarithromycin and week 2 of clarithromycin (all p-values > 0.05). there were no significant differences of the effect of clarithromycin in those subjects who had (n = 11) or had not (n = 9) had prior exposure to clarithromycin (all p-values > 0.05). our two week treatment period was not long enough to comprehensively assess for possible wearing off of medication effectiveness over time, which we and others have reported may be problematic in some hypersomnia patients treated with clarithromycin.12, 40 the difference between weeks 1 and 2 on sss might suggest the development of tolerance, although this was not seen in any other measure. this is, however, unlikely to explain the majority of the treatment benefit produced by clarithromycin in this study, given that a similar benefit was seen in patients not taking these medications, and because patients taking these medications had already found them to be ineffective in controlling their sleepiness. median values are indicated by the solid horizontal line inside the box, and the 25th and 75th percentiles are indicated by the upper and lower edges of the box.
emory researchers announce discovery of substance that may be linked to excessive sleeping gaba and histamine work together to control some central hypersomnolence syndromes are associated with a positive allosteric modulator of gaba-a receptors in cerebrospinal fluid. negative the macrolide antibiotic clarithromycin can enhance central nervous system excitability, possibly by antagonism of gaba-a receptors. enhancement of gaba, hypersomnia neurotransmitter, hypersomnia neurotransmitter, gaba-histamine, flumazenil, gaba and narcolepsy.
gaba-related hypersomnia occurs in people who have one of the central disorders of hypersomnolence (idiopathic hypersomnia, kleine-levin syndrome, narcolepsy, or hypersomnia due to a medical or psychiatric disorder) and have the somnogen in their cerebrospinal fluid (csf). dr. trotti’s research protocol translates the recent discovery of excess gaba-a receptor potentiation in the majority of cns hypersomnia patients into important “and the fact that there’s a difference suggests that (gaba-a receptors) might be related to the sleepiness in idiopathic hypersomnia,” she improvement in daytime sleepiness with clarithromycin in patients with gaba-related hypersomnia: clinical experience. j psychopharmacol. 2013. 54. ozaki a,, clarithromycin for idiopathic hypersomnia, clarithromycin sleep problems, clarithromycin hypersomnia reddit, histamine and idiopathic hypersomnia, gaba allergies, antihistamine gaba, histamine gaba receptor, azithromycin gaba, clarithromycin side effects, nct04026958.
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