background and purpose: the aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. to reach a sufficient statistical level, we introduced the concept of “composite endpoint” to pool the data related to sleep outcomes with similar significance and a consistent direction. based on the formula and endpoint definition, the values of the same endpoints in each trial were pooled first and then the data from different trials were pooled together for analysis. figure 2. forest plots of composite endpoint 1, composite endpoint 2, composite endpoint 3, and composite endpoint 4. except for composite endpoint 3, the treatment effects of gabapentin were superior to those of the placebo; a random-effects model. because it was impossible to distinguish absolutely true, partially true, and false sleep disturbance, we could not exclude the contribution of false sleep disturbance to the final treatment efficacy in patients with medical illness. through a systematic review and meta-analysis, this study for the first time systematically evaluated the clinical value of gabapentin for the treatment of sleep disorders. doi:10.5694/mja13.10620 6. kuriyama a, honda m, hayashino y. ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis.
gabapentin combined with naltrexone for the treatment of alcohol dependence. gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. a randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. a gastroretentive gabapentin formulation for the treatment of painful diabetic peripheral neuropathy: efficacy and tolerability in a double-blind, randomized, controlled clinical trial. gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia: a randomized, double-blind, placebo-controlled, multicentre study. the pittsburgh sleep quality index: a new instrument for psychiatric practice and research. principles and practice of sleep medicine. 457,586,590 p. citation: liu gj, karim mr, xu ll, wang sl, yang c, ding l and wang y-f (2017) efficacy and tolerability of gabapentin in adults with sleep disturbance in medical illness: a systematic review and meta-analysis.
our goal was to evaluate the benefits of gabapentin in the treatment of primary insomnia in patients. conclusions: gabapentin enhances slow-wave sleep in patients with primary insomnia. the aim of this study was to compare the efficacy of gabapentin with clonazepam for treating residual sleeping disturbances.
objectives: to evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (psg) and participant-reported sleep measures in a 5-h phase advance insomnia model. gabapentin was associated with significantly higher values of ksd sleep quality index and reported tst versus placebo; no other reported outcomes were significant. moreover, the participants treated with gabapentin showed a significant improvement in total sleep time, slow wave sleep (stage iii), and sleep efficiency (p < 0.05). conclusions: gabapentin for sleep appears to be less disruptive than are some of the older aeds.
we found that regardless the type of sleep outcomes, gabapentin displayed stable treatment efficacy for sleep disturbance in patients with conclusions: gabapentin enhances slow-wave sleep in patients with primary insomnia. it also improves sleep quality by elevating sleep gabapentin is a prescription drug used to treat insomnia. studies show it can increase the amount of deep sleep you get at night and improve your sleep quality., .
according to a 2010 study, gabapentin can improve sleep quality and slow-wave sleep (deep sleep), lower your risk of spontaneous nighttime wake- gabapentin and sleep most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. in a large review of 26 gabapentin has an average rating of 7.5 out of 10 from a total of 118 ratings for the treatment of insomnia. 69% of reviewers reported a positive experience,, .
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