granuloma annulare is a granulomatous skin disease of unknown aetiology. haematological neoplasms and adenocarcinomas are those most frequently found.1 the authors present the case of 68-year-old man with a recent diagnosis of hepatocellular carcinoma (figure 1). cutaneous histopathological examination of these lesions showed a lymphohistiocytic infiltrate with multinucleated giant cells in a palisade pattern in the papillary and reticular dermis and some foci of granulomatous reaction surrounding foci of altered collagen. this was compatible with the diagnosis of granuloma annulare (figure 3). palliative treatment with chemoembolisation was offered to the patient, but he died some months later.
histopathological examination (h&e (a) ×10 and (b) ×40): lymphohistiocytic infiltrate with histiocytes and multinucleated giant cells in a palisade pattern in the papillary and reticular dermis. the pathogenesis of granuloma annulare is unknown. features suggesting association with malignancy are atypical presentation, advanced age, pain and pruritus.3 in our patient, a true paraneoplastic course was difficult to establish because the patient died a couple of months later. in the cases where a neoplasm is found, treatment of the cancer should be the aim in the treatment of the granuloma annulare. immunosuppressors should always be balanced against the side effects in the neoplasm outcome.2 to the best of our knowledge, this is the first published case of an association between a disseminated granuloma annulare and a hepatocellular carcinoma. contributors tm involved in the conception, design, analysis and interpretation of data, drafting of the manuscript and gave final approval; amr involved in the acquisition of data, analysis and interpretation of data and gave final approval; jc involved in the critical revision of manuscript and gave final approval.
the exact cause of granuloma annulare is unknown. granuloma annulare may affect any area of the body. the exact cause of granuloma annulare is unknown (idiopathic). the prevalence of granuloma annulare in the general population is unknown. in many cases, the eruptions of granuloma annulare disappear without treatment (spontaneous remission).
more research is necessary to determine the long-term safety and effectiveness of topical puva therapy for individuals with granuloma annulare. treatment of disseminated granuloma annulare with 5-lipooxygenase inhibitor and vitamin e. br j dermatol. resolution of disseminated granuloma annulare following isotretinoin therapy. 1984;111:325-9. the information in nord’s rare disease database is for educational purposes only and is not intended to replace the advice of a physician or other qualified medical professional. please note that nord provides this information for the benefit of the rare disease community.
granuloma annulare is a benign dermatosis. although granuloma annulare usually occurs as an idiopathic condition, it has been described in oncology patients the pathogenesis of granuloma annulare is unknown. in the cases linked to cancer there is evidence suggesting that the mechanism of pathogenesis is related which malignancies have been associated with granuloma annulare? non-hodgkin lymphoma hodgkin lymphoma acute myelogenous leukemia chronic, .
granuloma annulare (ga) is an uncommon cutaneous disease characterized by popular primary lesions and a tendency to annular grouping. generalized variants can potentially involve any area of the skin. 1 ga is a benign condition that usually occurs as an idiopathic condition. granuloma annulare is a benign (not cancer), often chronic (long-lasting) skin disorder in which inflammation in the skin causes a raised, discolored rash or lumps under the skin. in most cases, rashes form on the hands, feet and forearms. detailed examination revealed the presence of an advanced ovarian cancer (mucinous cystadenocarcinoma) and stomach cancer (signet ring cell carcinoma), granuloma annulare is occasionally associated with diabetes or thyroid disease, most often when lesions are numerous or widespread. it may, granuloma annulare is a chronic degenerative skin disorder. the most common form is localized granuloma annulare, which is characterized by the presence of, .
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