lexapro and insomnia

because insomnia is one of the most common side-effects of lexapro, it is important to know the ins-and-outs of this medication, if you have been prescribed it for anxiety or depression and/or have a hard time falling and staying asleep at night. because serotonin is responsible for feelings of happiness and well-being, a higher level of serotonin in the brain can lead to lower levels of anxiety and depression. regardless, experts generally agree that the possibility of side-effects should not be a reason to avoid from or stop lexapro – if you need it. the fda reports that approximately, 10% of people who take lexapro for anxiety or depression experience a dry mouth. however, if it is determined that lexapro is the cause of your insomnia; this side-effect is usually temporary.




keep in mind that the goal of ssris is to boost your serotonin levels, the hormone/neurotransmitter responsible for your feelings of happiness and well-being. it is also important to keep in mind that anxiety and depression can also cause “sleeplessness,” so it is possible that it is not lexapro that is causing the insomnia. the good news is there are ways to relieve your anxiety or depression symptoms and still get a good night’s sleep! off-label indications for antidepressants in primary care: descriptive study of prescriptions from an indication based electronic prescribing system. escitalopram for the treatment of major depression and anxiety disorders. effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy perimenopausal and postmenopausal women with hot flashes: a randomized controlled trial.

hamilton anxiety scale (ham-a) scores, including and excluding the insomnia sleep item, in patients with insomnia and comorbid generalized anxiety disorder treated with placebo and escitalopram or eszopiclone and escitalopram. results  compared with treatment with placebo and escitalopram, treatment with eszopiclone and escitalopram resulted in significantly improved sleep and daytime functioning (p < .05), with no evidence of tolerance. the aims of this study were to examine (1) the hypnotic efficacy and safety of eszopiclone coadministered with the ssri escitalopram compared with escitalopram and placebo for patients with insomnia and gad and (2) whether coadministration of eszopiclone would increase the magnitude and/or accelerate the anxiolytic response compared with the antidepressant alone. the isi was completed at weeks 1, 4, 8, and 10; the sheehan disability scale was completed at weeks 4, 8, and 10; and the quality of life enjoyment satisfaction questionnaire was completed at weeks 8 and 10. at the week 8 visit, patients received single-blind placebo in place of eszopiclone or placebo, and they continued open-label escitalopram treatment for 2 weeks. the 50% anxiolytic response in total ham-a score was summarized for each treatment group and analyzed using the cochran-mantel-haenszel test of general association with no stratification factors.

median time to onset of anxiolytic response was reduced in the eszopiclone and escitalopram group compared with the placebo and escitalopram group based on a 50% reduction in ham-a scores from baseline (29 vs 32 days, respectively; p = .02). in patients with more severe anxiety at baseline (ham-a score ≥ the median score of 22), there were significant improvements in mean ham-a scores with eszopiclone and escitalopram relative to placebo and escitalopram at week 8 (– 14.3 vs – 12.5, respectively; p = .01), whereas in patients with less severe anxiety at baseline (ham-a score < 22), there were no significant differences between treatment groups at week 8 (– 9.0 vs – 8.5, respectively; p = .21). the clinical significance of the improvement in sleep measures is reflected in the significantly greater proportion of patients treated with eszopiclone and escitalopram having no clinically meaningful insomnia (47%) as assessed by the isi at the end of the double-blind treatment period compared with patients treated with placebo and escitalopram (33%; p < .001). the improvement in sleep, daytime functioning, anxiety, and depression observed in the eszopiclone and escitalopram group was not associated with markedly increased rates of adverse events or any related treatment-discontinuation adverse effects. in summary, we found that eszopiclone cotherapy significantly improved sleep with no evidence of tolerance in patients with comorbid insomnia and gad compared with escitalopram monotherapy. additional contributions: susan kornstein, md, made helpful comments in discussing the data and kimberly pfleeger, phd, of sepracor inc assisted in preparing the manuscript.

according to the fda, approximately 5% of people who use lexapro for anxiety or depression experience insomnia during the initial stage of some antidepressants may cause insomnia, making it difficult to get to sleep or stay asleep, so you may be tired during the day. consider these strategies: take the coadministration of eszopiclone and escitalopram was associated with rapid improvement in insomnia by week 1, demonstrated by changes in sleep onset,, .

more than 10% of patients reported insomnia while on lexapro, according to the fda, making it one of the most common side effects of the medication. many antidepressants, especially ssris, can cause insomnia due to their effect on the serotonergic system responsible for certain bodily functions, including sleep. insomnia is a common side effect of many antidepressants, including lexapro. for example, it’s listed as one of the most common adverse reactions experienced by people prescribed lexapro in fda documentation. according to data from the fda, more than five percent of people who use lexapro experience insomnia. in healthy women with menopausal hot flashes, treatment with escitalopram at doses of 10 or 20 mg/d relative to placebo reduced insomnia symptoms and improved in the interim, from a clinical perspective, escitalopram appears to be beneficial for the treatment of sleep problems in mdd and gad. most antidepressant drugs side effects are common, with insomnia often associated with lexapro. the fda has indicated that about 5% of patients, .

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