rem related sleep apnea

regression models were used to explore the associations between rem-sdb and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with nrem-ahi <10 events·h−1 and total ahi <10 events·h−1. this study evaluated the prevalence of rem-sdb in the general population and investigated the associations between rem-sdb and cardiovascular, metabolic and psychiatric comorbidities. two measures were made for waist and hip and the mean (expressed in centimetres) was used to assess the waist-to-hip ratio (whr). logistic regression models were used to estimate the association between rem-sdb and the presence of hypertension, diabetes, metabolic syndrome and depression. as rem-ahi increased there was a corresponding increase in mean age, bmi, whr and neck circumference, as well as in the prevalence of hypertension, diabetes and metabolic syndrome (table 1). logistic regression models were fitted to examine the associations for the entire cohort with metabolic syndrome, diabetes, hypertension and depression.

the results of the logistic regression models applied to this subgroup are shown in figure 3. there was a significant association of moderate-to-severe rem-sdb with both metabolic syndrome and diabetes, but not with hypertension or depression. to our knowledge, this is the first study demonstrating an independent association of rem-sdb with metabolic syndrome and diabetes in the general population. we previously reported a significant association between sdb severity and hypertension in the population-based hypnolaus sleep cohort [1]. we did not find a significant association between depression and rem-sdb besides a trend in the nrem-ahi <10 events·h−1 subgroup. the corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication. note: we only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.

the aim of the study was to compare rem-dependent and rem-independent, obstructive sleep apnea syndrome (osa) patients in relation to their daily sleepiness assessed by epworth sleepiness scale (ess). thus, we hypothesise, that daily-sleepiness may be more related to sdb confined to rem sleep rather than occurring independently of sleep stage and the severity of the disorder defined by ahi alone. therefore, the aim of this study was to compare rem-osa to nrem-osa patients in respect to daily somnolence assessed by ess15. the study was conducted in accordance with the amended declaration of helsinki. to measure the impact of sdb occurring in rem sleep we calculated rem related ahi (ahirem-related) dividing the number of rem apneas/hypopneas by tst and it was over 3 times higher in rem-osa (p < 0.001). as our study demonstrated, the ess as a measure of day-time sleepiness was similar in study groups, despite lower ahi in rem-osa group. it is plausible that non-interrupted rem is essential to the restorative properties of sleep; sdb in rem leads to arousals and as a consequence rem sleep fragmentation.

in mild to moderate nrem-osa group it can be highly variable and depends on percentage of sleep spent in a supine position, as majority of these patients have positional osa with the ratio ahiback/ahiside ≥ 2. ahi, arousals or desaturations, we posit that qualitative differences in osa phenotypes related to sdb occurring in different sleep stages may independently explain the severity of daily sleepiness. relation of sleepiness to respiratory disturbance index: the sleep heart health study. excessive daytime sleepiness in patients suffering from different levels of obstructive sleep apnoea syndrome. results of the wisconsin sleep cohort. the association between daytime sleepiness and sleep-disordered breathing in nrem and rem sleep. effect of cpap on blood pressure in patients with osa/hypopnea a systematic review and meta-analysis. created the concept of the study and performed statistical analysis.

the term rem-related obstructive sleep apnea (osa) is used loosely by sleep clinicians when the polysomnogram (psg) reveals obstructive although sleep apnea is often more pronounced during rapid eye movement (rem) sleep, the term “rem-related” sleep apnea has been used to label sleep-disordered compared with nrem sleep, rem sleep is associated with higher sympathetic activity and cardiovascular instability [15–17]. recent studies have shown an, rem related sleep apnea treatment, rem related sleep apnea treatment, mild sleep apnea but severe in rem, rem sleep apnea symptoms, rem related sleep disorder.

the term u201crem-relatedu201d osa has been coined to denote the occurrence of disordered breathing events that predominantly or exclusively manifest during rem sleepu2014an observation that is common in clinical practice and well recognized by healthcare professionals in sleep medicine. daily sleepiness may be stronger associated with apneas/hypopneas occurring in rem than nrem sleep. introduction. obstructive sleep apnea among those phenotypes, rem-related osa has been reported to account for 10–36% of patients with osa in sleep clinic cohorts (5), especially in patients severe obstructive sleep apnea (osa) that occurs exclusively during rem sleep is associated with recurrent cardiovascular events in those, treatment for rem apnea, rem sleep apnea complications.

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