patients with primary sjögren’s syndrome whose first symptoms are not mouth and eye dryness may experience more progressive and severe pulmonary manifestations during the course of their disease, a study reports. sjögren’s syndrome is an autoimmune disease characterized by the infiltration of immune cells into secretory glands — primarily the lacrimal and salivary glands. because systemic symptoms are the main determinants of a patient’s prognosis, early detection and treatment of such complications are a major concern among physicians. researchers at the peking university people’s hospital in china set out to compare the frequency and severity of lung disease between patients with and without sicca at disease onset. the majority of these patients were women (91.2 percent), with a mean age of 61 years. the other half had pulmonary symptoms — such as shortness of breath or coughing — joint pain, fever, blood or vessel problems, teeth loss, rashes, parotid gland swelling, or liver damage.
non-sicca patients required salivary gland biopsies or radiological examinations of the salivary glands more often than those with sicca at disease onset. patients without initial sicca also had lower levels of globulin, a marker of liver function and inflammation, and anti-ssa and/or anti-ssb autoantibodies, as well as elevated rheumatoid factor. their predicted total lung capacity and forced vital capacity — measures of lung function — were also lower than patients with initial sicca symptoms. “non-sicca is a common initial manifestation in primary sjögren’s syndrome with ild,” the researchers wrote. this site is strictly a news and information website about the disease. always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
the prevalence of pulmonary involvement in patients with ss is difficult to estimate. nearly one half of patients with ss in this series had nasal crusting and dryness on physical examination. the profile of the inflammatory infiltrate in the airways of patients with ss is similar to that of atopic asthma, and includes a large number of mast cells and neutrophils in addition to lymphocytes(17). currently, nsip is the most common subtype of ild in ss patients, with a prevalence ranging between 28% (25) and 61% (26). the prognosis is good and is dependent on the presence or absence of fibrosis.
the prevalence of uip among ss patients with ild is 17% (25). cysts, like fibrosis, are an irreversible manifestation of pulmonary ss and early diagnosis and treatment, especially in cases associated with lip, may successfully halt the process (44). malt lymphomas have a good prognosis at the time of diagnosis, and the prognosis is similar regardless of the involved organs. it is a rare complication of primary ss and less than 50 cases have been described in the literature. early identification and treatment is associated with improved outcome.
cough and shortness of breath due to lung disease; irregular heartbeat; nausea and heartburn; vaginal dryness or painful urination. exams and tests. a complete half of them experienced sicca as their first disease manifestation. the other half had pulmonary symptoms — such as shortness of breath or pulmonary involvement results in both increased morbidity and mortality. cough and dyspnea are common symptoms and may portend a number of pulmonary, sj gren s syndrome warning signs, sj gren s syndrome warning signs, sjogren’s syndrome weight gain, sjögren’s and asthma, sjögren’s syndrome lung disease treatment.
as healthy lung tissue is replaced by scar tissue, it becomes harder for oxygen to pass through the lungs and into the bloodstream. this results in shortness of breath. most people don’t notice the changes to their lungs at first and may think they’re becoming unfit or tired. sjögren’s syndrome can sometimes affect the lungs and cause problems such as: if you smoke, quitting may help reduce the risk of these conditions. read more this study shows that lung involvement in patients with primary sjögren’s syndrome is common and mostly subclinical. physiological, radiological, and when symptoms occur, they present with cough, dyspnoea and wheezing and may be isolated or associated with interstitial pneumonia [29]. although lung biopsy, sjögren’s syndrome weight loss, long-term effects of sjögren’s syndrome.
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