simvastatin modestly but significantly reduced sleep quality and increased sleep problems compared with pravastatin (pravachol), according to a large study of subjective sleep measures reported at the american heart association meeting. this may allow the drug to more readily cross the blood-brain barrier and impact serotonin or other sleep-related factors compared with statins such as pravastatin, which is the most hydrophilic. to test sleep outcomes prospectively, the researchers conducted a double-blind trial in which 1,000 men and postmenopausal women were randomized to placebo or equivalent, or modest doses of pravastatin (40 mg) or simvastatin (20 mg). at baseline, participants had ldl cholesterol in the 115 to 190 mg/dl range, for which statin treatment was considered optional at the time.
sleep quality and sleep problems were similar between treatment groups at baseline. sleep quality was significantly linked to tiredness and irritability, whereas sleep problems were correlated with tiredness, irritability, and cognition (all pmore patients taking simvastatin reported sleep as much worse than at baseline than did patients on placebo (p=0.015), and a similar trend was seen compared with pravastatin (p=0.093). in an exploratory analysis, there were no differences in unrestful sleep or other characteristics measured. source reference: golomb ba, et al “simvastatin but not pravastatin affects sleep: findings from the ucsd statin study” aha meeting 2007; abstract 3725. the material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.
a cholesterol-lowering drug appears to disrupt sleep patterns of some patients, researchers reported at the american heart association’s scientific sessions 2007. in the largest study of its kind, researchers compared two types of cholesterol-lowering drugs called statins — simvastatin, which is lipophilic (soluble in fats), and pravastatin, which is hydrophilic (soluble in water). the brain controls sleep, and many of the brain’s nerve cells are wrapped in a fatty insulating sheath called myelin. a significantly greater number of individuals taking simvastatin reported sleep problems than those taking either pravastain or the placebo,” golomb said. “most (researchers) didn’t see a difference in sleep, but they had short durations of follow-up and enrolled just a handful of people — often fewer than 20, which was not enough to see a difference unless it was very large.
“one of these studies did report a significant difference between pravastatin and simvastatin. they assessed outcomes with the leeds sleep scale, a visual analog scale of sleep quality, and a rating scale of sleep problems. “those who reported developing much worse sleep on study medication also showed a significant adverse change in aggression scores compared to others,” golomb said “we should also point out that although the average effect on sleep was detrimental on simvastatin, this does not mean that everyone on simvastatin will experience worse sleep.” “patients taking simvastatin who are having sleep problems should consult with their doctor,” golomb said. get the latest science news with sciencedaily’s free email newsletters, updated daily and weekly. or view hourly updated newsfeeds in your rss reader: tell us what you think of sciencedaily — we welcome both positive and negative comments.
the current evidence, from well-run research trials of more than 100,000 patients, is that statins do not cause insomnia or any other sleep disturbance, medications that commonly cause insomnia include antidepressants, decongestants, beta blockers, and statins. talk to your provider if you insomnia is listed as a possible side effect on the labeling of all statin drugs. the findings were reported at the american heart, atorvastatin and insomnia, atorvastatin and insomnia, rosuvastatin insomnia, which statins do not cause insomnia, drugs that keep you awake all night.
researchers have found that fat-soluble statins u2014 which include lipitor, mevacor, vytorin and zocor u2014 are more likely to cause insomnia or nightmares because they can more easily penetrate cell membranes and make their way across the blood-brain barrier, which protects the brain from chemicals in the blood. accumulating databases from the us food and drug administration adverse event reporting system (faers) suggest that statin use is associated with an increased risk of sleep disturbances including insomnia . in other studies hallucinations and nightmares during statin therapy were also observed [6, 7]. statins side effects: some statins can penetrate cell membranes easier and make their way across the blood-brain barrier, which protects the “that being said, however, insomnia is an adverse event associated with statins and is included in the product label for this class of medicines “multi-methodological approaches using different methodologies, algorithms, and databases strongly suggest that statin use is associated with an, which drugs cause sleeplessness, atorvastatin nightmares.
When you try to get related information on statins and insomnia, you may look for related areas. atorvastatin and insomnia, rosuvastatin insomnia, which statins do not cause insomnia, drugs that keep you awake all night, which drugs cause sleeplessness, atorvastatin nightmares.