the .gov means it’s official. before sharing sensitive information, make sure you’re on a federal government site. rationale: a low respiratory arousal threshold is a physiological trait involved in obstructive sleep apnea (osa) pathogenesis. objectives: we aimed to examine how trazodone alters osa severity and arousal threshold.
we hypothesized that trazodone would increase the arousal threshold and improve the apnea/hypopnea index (ahi) in selected patients with osa. fifteen unselected subjects with osa (ahi ≥ 10/h) underwent a standard polysomnogram plus an epiglottic catheter to measure the arousal threshold. measurements and main results: compared with placebo, trazodone resulted in a significant reduction in ahi (38.7 vs. 28.5 events/h, p = 0.041), without worsening oxygen saturation or respiratory event duration. trazodone was not associated with a significant change in the non-rem arousal threshold (-20.3 vs. -19.3 cm h2o, p = 0.51) compared with placebo. conclusions: these findings suggest that trazodone could be effective therapy for patients with osa without worsening hypoxemia.
trazodone at 100 mg increased the effort-related arousal threshold in response to hypercapnia in obstructive sleep apnoea patients and allowed them to tolerate higher co2 levels. based on this concept, some authors have tried to treat sleep apnoea patients by increasing the arousal threshold with sedatives, such as benzodiazepines, without much success 3. this failure may be due to a myorelaxant effect of benzodiazepine on upper airway dilator muscles. once in place, the balloon was partially inflated with 0.5 ml of air and connected to a calibrated pressure transducer. an arousal was defined as an abrupt shift in eeg frequency which included the theta-alpha pattern and/or a frequency >16 hz (but not spindles) of ≥3 s duration.
to compare the respiratory effort and pet,co2 prior to arousal between placebo and trazodone, a paired t-test was used, as each subject was his/her own control. the main finding of the present study was that, in osa patients, trazodone increased the respiratory effort-related arousal threshold in response to hypercapnia and allowed these individuals to tolerate a higher co2 level without arousal. as there was such a clear effect of trazodone on the co2-induced arousal threshold, the present authors were surprised by the lack of a significant effect on the arousal threshold in response to a stepwise decrease in cpap. in conclusion, trazodone increased the respiratory effort-related arousal threshold in response to hypercapnia in obstructive sleep apnoea patients and allowed them to tolerate a higher co2 level. note: we only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.
conclusions: these findings suggest that trazodone could be effective therapy for patients with osa without worsening hypoxemia. future studies should focus on the main finding of the present study was that, in osa patients, trazodone increased the respiratory effort-related arousal threshold in response to hypercapnia trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold without major impairment in dilator, related health topics, related health topics, does trazodone affect your breathing, trazodone cause sleep apnea, does trazodone make you snore.
based on studies showing that increasing the arousal threshold with a different hypnotic improves sleep apnea severity, we hypothesize that trazodone modestly decreases osa severity and improves minimum oxygen saturation in ischemic stroke patients with osa. typically, the there’s no pill for sleep apnea, but some prescription and over-the-counter drugs may help with symptoms or causes of the condition., trazodone side effects, trazodone sleep apnea reddit, trazodone morning wood, trazodone arousal, trazodone for sleep reviews, trazodone and copd, how to sleep after stopping trazodone, respiratory arousal threshold, trazodone sleep walking, trazodone half-life for sleep.
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