the aim of this review is to summarise current knowledge on the association between osas and vitamin d levels. the pathogenesis of vitamin d insufficiency in osas is multifactorial and incompletely understood. the results from a systematic review of 16 randomised controlled trials on the effects of treatment with vitamin d on muscle function supported a beneficial effect of vitamin d supplementation on muscle strength and function in the elderly . the main results of the studies examining the relationship between serum levels of vitamin d and osas are presented in table 1. several works failed to demonstrate a relationship between serum vitamin d levels and osas severity [28, 29]. of note, some of the studies failing to demonstrate an association between osas severity and serum vitamin d levels reported higher mean 25(oh)d levels compared with those showing a relationship between vitamin d and ahi [32, 33].
in copd and asthma patients, adiposity has been a significant predictor of low serum levels of vitamin d [45, 46]. obesity affects vitamin d status and further studies are needed to determine the complex interaction between them in osas patients, as well as to establish the role of supplemental vitamin d in those patients . thus, the association between vitamin d insufficiency and hypoxia in osas may be mediated by mechanisms involving hif-1α and vegf. table 2 summarises studies examining the effect of cpap treatment on vitamin d levels in osas patients. taken together, the data suggest a positive effect of cpap therapy on serum levels of vitamin d and factors such as duration of the intervention, sex and obesity may affect this interaction. the positive effects of vitamin d in the comorbidities associated with osas (e.g.
in conclusion, this meta-analysis demonstrates that vitamin d deficiency is associated with a higher risk of sleep disorders in the population. vitamin d has both a direct and an indirect role in the regulation of sleep. although vitamin d deficiency has been associated to sleep disorders, there is  of importance, low vitamin d levels seem to be significantly associated with longer time to fall asleep  and excessive daytime sleepiness,  underlying, vitamin d causing insomnia reddit, vitamin d causing insomnia reddit, melatonin and vitamin d together, vitamin d and sleep apnea, when to take vitamin d for sleep.
being deficient in vitamin d can lead to a host of sleep issues, including sleep disruption, insomnia, and overall poor sleep quality. “a deficiency in vitamin d has been associated with many changes in sleep such as fewer sleeping hours, and sleep that is less restful and restorative,” said dr. the authors reported that vitamin d improved sleep quality, reduced sleep latency, raised sleep duration and improved subjective sleep quality [ vitamin d receptors have been identified in several brain areas, including the hypothalamus which, among others, regulates alterations in the sleep–wake cycle [ the science of vitamin d and sleep several studies have shown an association between vitamin d levels and different measures of sleep. low, vitamin d deficiency symptoms, magnesium and vitamin d for sleep.
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