vitamin d deficiency and insomnia

in this regard, studies demonstrated anatomic and epidemiological connections between sleep problems and vitamin d deficiency. [2] of importance, low vitamin d levels seem to be significantly associated with longer time to fall asleep [3] and excessive daytime sleepiness, [4] underlying conditions in sleep restricted individuals. to date, no studies specifically addressed the effects of sleep deprivation on vitamin d levels. in light of the recent findings by littlejohns and colleagues, [1] disturbed sleep, a long known condition linked to aging, [5] could indirectly contribute to the development of dementia and alzheimer disease.




vitamin d and the risk of dementia and alzheimer disease. the link between vitamin d metabolism and sleep medicine. 3.shiue i. low vitamin d levels in adults with longer time to fall asleep: us nhanes, 2005-2006. int j cardiol 2013;168:5074-5075. vitamin d, race, and excessive daytime sleepiness.

studies have demonstrated a possible action of vitamin d in the regulatory mechanisms of both sleep and pain. then, the calcitriol-vdr-rxr complex couples to a specific sequence of dna known as the vitamin d response element (vdre), which is associated with promoters of several target genes and co-activator molecules (holick et al. regarding the mechanisms of pain sensitization, vitamin d seems to stimulate anti-inflammatory processes in some cases and thus to relieve the painful sensation of many diseases (adorini & penna 2008, osunkwo et al. in this review, we aim to explore the current knowledge about the association between sleep and pain and to consider the role that vitamin d may play in this relationship. another important factor in the regulation of sleep is the presence of melatonin, an endogenous hormone produced by the pineal gland and responsible for the regulation of circadian rhythms. the association between sleep disorders and 25ohd values has increased in the last decade (andersen & tufik 2012, bozkurt et al. the possible mechanisms involved in this association are not clear, suggesting that additional studies are required to understand the potential role of vitamin d in physiological sleep mechanisms. it is important to highlight the heterogeneous characteristics of the sample in this study, such as age, gender and the presence of comorbidities, which hamper the establishment of a clear relationship between vitamin d and sleep maintenance. the mechanism of narcolepsy is attributed to the decrease in the concentration of hypocretin, a neuropeptide responsible for wakefulness in the cns. the authors found a trend of improvement in sleep quality in the high-vitamin d supplemented group compared to the low-vitamin d supplemented one (600 iu/day) (rorie et al. the accumulation of these cells in inflammatory processes leads to opioid expression, with antinociceptive effects (marchand et al. in fibromyalgia, a diffuse chronic pain syndrome, there are reports of an inverse relationship between serum 25ohd and pain. in rheumatic diseases, such as rheumatoid arthritis or osteoarthritis, the results for the inverse correlation between vitamin d and pain complaints are in the same direction (table 2) (gopinath & danda 2011, higgins et al. the use of animal models has provided a better understanding of the effects of sleep on pain and vice-versa, mimicking the physiological and behavioral manifestations observed in humans (andersen et al. the results showed that the treated group had a decrease in mean pain score at the end of the study, and sleep quality was improved compared to placebo. based on the literature, vitamin d status seems to have an important role in the bidirectional relationship observed between sleep and pain. the risk factors for the decrease of vitamin d status in this study were ethnicity, obesity and age. the vitamin d supplementation in sleep conditions associated with vitamin d deficiency or insufficiency may bring benefits to the well-being and quality of life of patients. journal of clinical sleep medicine 8 699. (doi:10.1046/j.1365-2826.2003.00989.x) çakır t, doğan g, subaşı v, filiz mb, ülker n, doğan şk & toraman nf 2015 an evaluation of sleep quality and the prevalence of restless leg syndrome in vitamin d deficiency. in principles and practice of sleep medicine, edn 6, pp 15–24. (doi:10.1016/j.jchemneu.2004.08.006) eyles dw, liu py, josh p & cui x 2014 intracellular distribution of the vitamin d receptor in the brain: comparison with classic target tissues and redistribution with development. (doi:10.1016/j.jsmc.2014.02.007) franklin ka & lindberg e 2015 obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.

(doi:10.1210/jc.2011-0385) huang w, shah s, long q, crankshaw ak & tangpricha v 2013 improvement of pain, sleep, and quality of life in chronic pain patients with vitamin d supplementation. (doi:10.5664/jcsm.6378) kheirandish-gozal l, peris e & gozal d 2014 vitamin d levels and obstructive sleep apnoea in children. journal of clinical sleep medicine 11 603–607. nature and science of sleep 5 37–42. (doi:10.1111/j.1365-2141.2010.08458.x) ozgurhan g, vehapoglu a, vermezoglu o, temiz rn, guney a & hacihamdioglu b 2016 risk assessment of obstructive sleep apnea syndrome in pediatric patients with vitamin d deficiency: a questionnaire-based study. (doi:10.1371/journal.pone.0155835) saper cb, scammell te & lu j 2005 hypothalamic regulation of sleep and circadian rhythms. (doi:10.1007/s12020-015-0547-4) smith ak, togeiro sm, tufik s & roizenblatt s 2009 disturbed sleep and musculoskeletal pain in the bed partner of patients with obstructive sleep apnea. journal of sleep research 9 335–352. the vitamin d supplementation in sleep conditions associated with vitamin d deficiency or insufficiency may bring benefits to the well-being and quality of life of patients. journal of clinical sleep medicine 8 699. (doi:10.1046/j.1365-2826.2003.00989.x) çakır t, doğan g, subaşı v, filiz mb, ülker n, doğan şk & toraman nf 2015 an evaluation of sleep quality and the prevalence of restless leg syndrome in vitamin d deficiency. neurobiology of sleep and circadian rhythms 3 1–9. (doi:10.1016/j.jchemneu.2004.08.006) eyles dw, liu py, josh p & cui x 2014 intracellular distribution of the vitamin d receptor in the brain: comparison with classic target tissues and redistribution with development. (doi:10.1016/j.jsmc.2014.02.007) franklin ka & lindberg e 2015 obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea. (doi:10.1210/jc.2011-0385) huang w, shah s, long q, crankshaw ak & tangpricha v 2013 improvement of pain, sleep, and quality of life in chronic pain patients with vitamin d supplementation. (doi:10.5664/jcsm.6378) kheirandish-gozal l, peris e & gozal d 2014 vitamin d levels and obstructive sleep apnoea in children. journal of clinical sleep medicine 11 603–607. nature and science of sleep 5 37–42. (doi:10.1111/j.1365-2141.2010.08458.x) ozgurhan g, vehapoglu a, vermezoglu o, temiz rn, guney a & hacihamdioglu b 2016 risk assessment of obstructive sleep apnea syndrome in pediatric patients with vitamin d deficiency: a questionnaire-based study. (doi:10.1371/journal.pone.0155835) saper cb, scammell te & lu j 2005 hypothalamic regulation of sleep and circadian rhythms. (doi:10.1007/s12020-015-0547-4) smith ak, togeiro sm, tufik s & roizenblatt s 2009 disturbed sleep and musculoskeletal pain in the bed partner of patients with obstructive sleep apnea. (doi:10.1016/s1389-9457(08)70013-3) wali s, shukr a, boudal a, alsaiari a & krayem a 2015 the effect of vitamin d supplements on the severity of restless legs syndrome. the vitamin d supplementation in sleep conditions associated with vitamin d deficiency or insufficiency may bring benefits to the well-being and quality of life of patients.

in conclusion, this meta-analysis demonstrates that vitamin d deficiency is associated with a higher risk of sleep disorders in the population. although the cause and consequence between sleep impairment and vitamin d deficiency is not yet fully elucidated, this suggests a bidirectional relationship. we based on our clinical case we suggest to make consider vitamin d deficiency as a probable cause of sleep disturbances and check the levels as a, related conditions, related conditions, vitamin d causing insomnia reddit, vitamin d deficiency symptoms, melatonin and vitamin d together.

being deficient in vitamin d can lead to a host of sleep issues, including sleep disruption, insomnia, and overall poor sleep quality. “a deficiency in vitamin d has been associated with many changes in sleep such as fewer sleeping hours, and sleep that is less restful and restorative,” said dr. other studies that have analysed the relationship between sleep patterns and vitamin d levels found that vitamin d deficiency is associated with sleep disorders, such as sleep apnea, as well as disrupted sleep and less sleep overall. lack of vitamin d can trigger insomnia, whereas achieving quality sleep can help your body better absorb this vital nutrient. both lack of sleep there’s a growing body of research showing vitamin d affects both how much sleep we get and how well we sleep. a recent study found vitamin d sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin d. poor sleep efficiency and sleep, when to take vitamin d for sleep, magnesium and vitamin d for sleep, vitamin d and sleep apnea, vitamin d and melatonin immune system, sources of vitamin d, vitamin k2 and sleep, vitamin k sleep, vitamin d and sleep paralysis, vitamin d deficiency and sleepiness, vitamin d deficiency and nightmares.

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